生命創成探究センター・基礎生物学研究所
神経分子動態生物学グループ・神経細胞生物学研究室
原著論文
Horio, T., Ishikura, Y., Ohashi, R., *Shiina, N. (2023) Regulation of RNG105/caprin1 dynamics by pathogenic cytoplasmic FUS and TDP-43 in neuronal RNA granules modulates synaptic loss., Heliyon, 9 (6), e17065, doi: 10.1016/j.heliyon.2023.e17065
Yamashita, A., Shichino, Y., Fujii, K. , Koshidaka, Y., Adachi, M., Sasagawa, E., Mito, M., Nakagawa, S., Iwasaki, S., Takao, K., *Shiina, N. (2023) ILF3 prion-like domain regulates gene expression and fear memory under chronic stress., iScience, 26(3):106229, doi: 10.1016/j.isci.2023.106229
Nakazawa, K., Scichino, Y., Iwasaki, S., *Shiina, N. (2020) Implications of RNG140 (caprin2)-mediated translational regulation in eye lens differentiation., J. Biol. Chem. 295, 15029-15044., doi: 10.1074/jbc.RA120.012715
*Shiina, N. (2019) Liquid- and solid-like RNA granules form through specific scaffold proteins and combine into biphasic granules. J. Biol. Chem. 294, 3532-3548., doi: 10.1074/jbc.RA118.005423.
†Nakayama, K., †Ohashi, R., Shinoda, Y., Yamazaki, M., Abe, M., Fujikawa, A., Shigenobu, S., Futatsugi, A., Noda, M., Mikoshiba, K., Furuichi, T., Sakimura, K., *Shiina, N. (2017) RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. eLife 6:e29677, doi: 10.7554/eLife.29677. (†These authors contributed equally., *Corresponding author)
Ohashi, R., Takao, K., Miyakawa, T., *Shiina, N. (2016) Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 6, 20775,doi: 10.1038/srep20775
Tsuboi, D., Kuroda, K., Tanaka, M., Namba, T., Iizuka, Y., Taya, S., Shinoda, T., Hikita, T., Muraoka, S., Iizuka, M., Nimura, A., Mizoguchi, A., Shiina, N., Sokabe, M., Okano, H., Mikoshiba, K., Kaibuchi, K. (2015) Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. Nat. Neurosci. 18, 698-707.
*Shiina, N., Nakayama, K. (2014) RNA granule assembly and disassembly modulated by nuclear factor associated with dsRNA 2 and nuclear factor 45. J. Biol. Chem. 289, 21163-21180 doi: 10.1074/jbc.M114.556365.
*Shiina, N., Yamaguchi, K., Tokunaga, M. (2010) RNG105 deficiency impairs the dendritic localization of Na+/K+ ATPase subunit isoforms and leads to the degeneration of neuronal networks. J. Neurosci. 30, 12816-12830.
*Shiina, N., Tokunaga, M. (2010) RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain. J. Biol. Chem. 285, 24260-24269.
*Shiina N., Shinkura K., Tokunaga M. (2005) A novel RNA-binding protein in neuronal RNA granules: Regulatory machinery for local translation. J. Neurosci. 25, 4420-4434.
Mimori-Kiyosue Y., Shiina N., Tsukita S. (2000) The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules. Curr. Biol. 10, 865-868.
Mimori-Kiyosue Y., Shiina N., Tsukita S. (2000) Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells. J. Cell Biol. 148, 505-518.
Kubo A., Sasaki H., Yuba-Kubo A., Tsukita S., *Shiina N. (1999) Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J. Cell Biol. 147, 969-980.
*Shiina N., Tsukita S. (1999) Mutations at phosphorylation sites of Xenopus microtubule-associated protein 4 affect its microtubule-binding ability and chromosome movement during mitosis. Mol. Biol. Cell 10, 597-608.
Shiina N., Gotoh Y., Kubomura N., Iwamatsu A., Nishida E. (1994) Microtubule severing by elongation factor 1 alpha. Science 266, 282-285.
Ohta K., Shiina N., Okumura E., Hisanaga S., Kishimoto T., Endo S., Gotoh Y., Nishida E., Sakai H. (1993) Microtubule nucleating activity of centrosomes in cell-free extracts from Xenopus eggs: involvement of phosphorylation and accumulation of pericentriolar material. J Cell Sci. 104, 125-137.
Shiina N., Gotoh Y., Nishida E. (1992) A novel homo-oligomeric protein responsible for an MPF-dependent microtubule-severing activity. EMBO J. 11, 4723-4731.
Shiina N., Moriguchi T., Ohta K., Gotoh Y., Nishida E. (1992) Regulation of a major microtubule-associated protein by MPF and MAP kinase. EMBO J. 11, 3977-3984.
Gotoh Y., Nishida E., Matsuda S., Shiina N., Kosako H., Shiokawa K., Akiyama T., Ohta K., Sakai H. (1991) In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase. Nature 349, 251-254.